September 27, 2023
Location: SB 156
Time: 12:00 pm
Presenter: Dr. Tuan Phan
Ruthenium Complexes: A Promising Alternative to Platinum-Based Compounds in Medicinal Chemistry
Abstract: In the late 1960s, scientists at Michigan State University discovered cisplatin’s potential as an anti-cancer treatment while studying bacterial cell development under electric fields. This marked a new era in metal-based chemotherapy research. Despite effective platinum-based cancer treatments, limitations like drug resistance and side effects have spurred research for alternative metal-based anti-cancer agents. Ruthenium compounds, particularly known for forming octahedral complexes, have garnered attention. Yet no ruthenium complex is approved for therapeutic use. The Phan Lab at TSU focuses on creating robust, reactive, selective, and soluble ruthenium complexes for challenging conditions.
Tuan Phan holds the position of chemistry professor at Texas Southern University. He earned his Ph.D. in organic chemistry from the University of Houston. His research pursuits encompass two primary areas: ruthenium complexes and environmental chemistry. He has served as a research advisor for the Ph.D. in Environmental Toxicology and Master of Chemistry programs. In addition, he has served as a research mentor to many undergraduate students.