COLLEGE OF SCIENCE,
ENGINEERING AND
TECHNOLOGY
Associate Professor
SB 303A/104GH | (713) 313.4231
yakubu_ma@tsu.edu
Curriculum Vitae

Education and Training

  • 1979-1982 B.Sc. Honors,University ofIbadan,Nigeria(Pharmacology
    and Therapeutics)
  • 1988-1989 Postgraduate Certificate,StowCollege, Glasgow
    (Management)
  • 1986-1989 Ph.D,University of Glasgow,Scotland. (Materia Medica/
    Pharmacology)

SPECIAL TRAINING

  • 1989 -1990 Postdoctoral Training, University Dept of Medicine &
    Therapeutics, Glasgow. (Prof John L. Reid)
  • 1990 -1992 Postdoctoral Associate,MichiganStateUniversityDept of
    Molecular Microbiology.Lansing. (Prof Felipe Kierszenbaum)..
  • 1992 -1994 NIH Postdoctoral Fellow,UniversityofTennessee, Dept of
    Physiology,Memphis. (Prof Charles W. Leffler).

HONORS AND AWARDS
NSF Panelist 2013 NSF Graduate Research Fellowship Program (GRFP) Bridges Faculty to the Professoriate: Institute on Teaching and Mentoring (Compact Faculty diversity/SREB) 2012 Admitted Member: Mission Connect-The Institute for Rehabilitation and
Research (TIRR) 2011

TSU Faculty Excellence Award April 2011
Co-Chair, Vasospasm Signal Transduction Session: 10th International
Conference on Cerebral Vasospasm, Chongqing, China, October 8-12, 2009.
First Place: Best Oral Presenter, TSU Research Week 2009.
Chair and moderator: NHLBI 11th Annual Cardiovascular Research Awardees session Nov. 2003 (Orlando, FL)
NIH AREA award 2002-2006
Editor: BioMed Scientist 2002-
NIH: Scientist Award Co-PI 2001-
AHA (SE-Affiliate) Grant-In-Aid 2000-2003
NIH Research award 1996-2000
AHA (TN Affiliate) Grant-In-Aid 1996-1998
University of Tennessee Medical Group Research Award 1995-1996
Univ. TN, Memphis Award for Outstanding Services to the Science Enrichment Program 1992-1997.
NIH Postdoctoral Fellow, 1990-1992
British Medical Research Council Postdoctoral Research Assistantship, 1989-1990
The University of Maiduguri Study Fellowship, 1985-1989
Benue State Government Scholarship, 1979-1982

Research Interests

Field 1: Environmental Toxicants and Toxicology
Field 2: Vascular and Cerebrovascular Diseases: Diabetes, Hypertension, Stroke, Brain Injury
Field 3: Drug Development and Alternative Medicine: Synthesis and Evaluation of Metal complexes and Herbal Plants for Biological Activities

Research/Scholarly Activities

CURRENT AREA OF RESEARCH

  1.  Synthesis and evaluation of metal complexes with thiourea/aromatic N-ligands as anticancer agents
  2.  Molecular consequences of exposure to complex chemical mixtures
  3.  Profiling and analysis of emerging contaminants in Houston drinking water sources.
  4.  Analysis of herbal/ medicinal plants and their potential in alternative medicine and therapeutic
  5.  Investigation of molecular targets for stroke treatments and cerebrovascular dysfunction
  6.  Integrated analysis of exposure to single and multiple pesticides
  7.  Environmental forensic: An integrated environmental research

PUBLICATIONS

Research Articles

Yakubu, MA, Sofola, OA, Igbo, I, nd Adebayo, AO. Streptozotocin-induced diabetes attenuates cAMP, nitric oxide synthase, and bradykinin-mediated relaxations. Bratislava Medical Journal 113, 2, 59-63, 2012; doi:10.4149/BLL_2012_014

Yakubu, MA, Anozie O, Nsaif, RH and Oyekan AO. Differential effects of tyrosine kinase protein kinase C on acute subarachnoid hemorrhage-induced changes in cerebral hemodynamics in rats. Brain Research (In review)

Yakubu, MA, Nsaif, RH and Oyekan AO. Regulation of PPAR expression and NO production in cerebrovascular endothelial cells by PKC. International Journal of Biomedical Sciences and Clinical Medicine (Bratislava Medical Journal) 2010; 111 (5), 258-264.

Anozie O, Ross R, Oyekan OA, Yakubu, MA. Differential modulation of bradykinin-induced relaxation of endothelin-1 and phenylephrine contractions of rat aorta by reactive oxygen species. Acta Pharmacologia Sinica. 2007; 28(10): 1566-1572.doi: 10.1111/j.1745-7254.2007.00631.x

Yakubu, MA, Nsaif, RH and Oyekan, OA. PPARI^+- activation-mediated regulation of ET-1 production via nitric oxide and protein kinase C signaling pathways in piglet cerebral microvascular endothelial cell culture. J Pharmacol Exp Ther. 2007, 14; 320(2):774-81; 2006 Nov 14; DOI: 10.1124/jpet.106.104992

SELECTED Abstracts:

  1. 1. Yakubu MA, Omobowale TO, Oyagbemi AA. Adedapo AA. (2016) Azadirachta Indica Ameliorates Ischemia/Reperfusion- and Hypertension-Induced Cardio-Renal Dysfunctions Mediated by Oxidative Stress. BIT’s 6th Annual International Congress of Medichem-2016 Theme: Efficient Creators of Future Therapy, Nanjing, China, November 16-19, 2016.
  2.  Yakubu MA. (2016) The paradox of environmental poisonous gases: From environmental rotten egg hydrogen sulfide to gaso-therapeutics at the bedside. 13th International Symposium on Recent Advances in Environmental Health Research to be hosted by Jackson State University, September 11-14, 2016 at the Jackson Marriott Hotel in Jackson, Mississippi
  3.  Yakubu MA, Brinkley NS, and Bessac B. (2016) Lindane (g-Hexachlororcclohexane) Exposure Impairs Ca2+-Mediated Vascular Reactivity. 13th International Symposium on Recent Advances in Environmental Health Research to be hosted by Jackson State University, September 11-14, 2016 at the Jackson Marriott Hotel in Jackson, Mississippi.
  4.  Adedapo, AA, Oyagbemi AA, Fagbohun OA, Omobowale TO, Yakubu MA (2016). Evaluation of the anticancer properties of the methanol leaf extract of Chromolaena odorata on HT29 lung cancer cell line. FASEB J April 2016 30:1193.6
  5.  Oyagbemi A., Omobowale T., Olowu, ER., Adedapo A., Oyekan AO., and Yakubu MA (2016) Kolaviron attenuated arsenic acid-induced cardiovascular dysfunction by enhancing antioxidant defense system and inhibiting inflammatory and apoptotic signaling pathways FASEB J April 2016 30:939.5

Research Grants

FUNDED Grants:

AFSCAN Research Award (UK) Molecular Characterization of Canine Parvovirus-2 Viruses Circulating in Dogs in Nigeria $9,045 (2016-2018): PI: Omóbòwálé TO, (University of Ibadan College of Veterinary Medicine, Collaborator/Mentee); Co-PI: Yakubu, MA.
IIE Grantee ID: 15410197: Carnegie African Diaspora Fellowship $25,650 (2014-2015): PI: Yakubu MA.
5R25HL003674-08: NIH: TSU Research Scientist Award: $3,975,708 (2001-2013) Co-PI: Yakubu MA.
1R15HL70669-01: NIH: Regulation of Cerebral Microvascular endothelin production (2002-2008). $180,802 PI: Yakubu, MA.
AHA (SE-Affiliate) Grant-In-Aid: Mechanisms of Inhibition of endothelial cyclooxygenase by blood hemolysates, $120,000 (2000-2002) PI: Yakubu, MA.
NIH Supplementary Award. Regulation of Cerebral Microcirculation. $250,000 (1996-2000) Awardee: Yakubu, MA,

FASEB/MARC: Grant writing Seminar/Workshop Award at Orlando, FL. ($1,900) Aug. 1999.
AHA (TN Affiliate) Grant-In-Aid. Roles of ET-1 and LPA in hematoma-induced changes in cere­bral microcirculation. $50,000 (1996-1998) PI: Yakubu, MA
University of Tennessee Medical Group Research Award. Hematoma and cerebral vasoreactivity: Role of endothelin-1. $12,450, (1995-1999) PI: Yakubu, MA